Ghost of Tsushima PC has input lag during fast combat on my MSI A520M-A PRO; do I need to calibrate polling?

When performing a quick draw attack, the feedback felt a fraction of a second late, which is absolutely lethal in an action game. Using a latency tester, I found that the USB ports on my MSI A520M-A PRO were dropping from 1000Hz to 500Hz whenever the CPU was under load, causing response spikes between 6-15ms. I tried swapping between USB 2.0 and 3.0 ports, but the fluctuation was there regardless, which made me really paranoid about my hardware. I eventually went into the BIOS, changed the USB mode from 'Auto' to 'Enabled', and killed every single power-saving option for the ports. The response time finally settled into a rock-solid 2-4ms range. I did find that some of my older USB peripherals stopped being recognized, but setting those specific ports back to compatibility mode solved it. Chipset temps were 52-58℃. I verified the final response parameters with a professional input lag tool.